Maxwell Enterprises

Iverbest 12 mg is a medication containing Ivermectin 12 mg as its active ingredient. It is commonly prescribed for the treatment of various parasitic infections.

• Ivermectin (12 mg): A broad-spectrum antiparasitic medication.

1. Treatment of Parasitic Infections:
   • Strongyloidiasis: Intestinal threadworm infections.
   • Onchocerciasis: River blindness caused by Onchocerca volvulus.
   • Lymphatic Filariasis (off-label use): Often used in combination with other drugs.
   • Scabies (off-label use): Effective for crusted or resistant scabies.
   • Head Lice (off-label use): Used in severe cases or where topical treatments have failed.

• Ivermectin works by binding to glutamate-gated chloride channels in the parasites' nerve and muscle cells. This action causes paralysis and death of the parasite, effectively eliminating the infection.

• Typical Dosage: Depends on body weight and the infection being treated.
  • The standard dose is 200 mcg per kg of body weight as a single dose. Your doctor may adjust the dose based on your condition.
• How to Take:
  • Swallow the tablet with water on an empty stomach, usually 1-2 hours before a meal.
  • Follow your doctor’s instructions for repeat doses, if required.

1. Medical History:
   • Inform your doctor if you have liver or kidney issues, any neurological disorders, or allergies to Ivermectin.
2. Pregnancy and Breastfeeding:
   • Consult your doctor before use; it is typically avoided unless necessary.
3. Alcohol:
   • Avoid alcohol during treatment as it may increase side effects like dizziness.
4. Driving or Operating Machinery:
   • May cause drowsiness or dizziness; exercise caution.

1. Common Side Effects:
   • Nausea, diarrhea, fatigue, dizziness, or mild abdominal pain.
2. Less Common Side Effects:
   • Skin rash, itching, or swelling.
3. Rare but Serious:
   • Allergic reactions (e.g., hives, difficulty breathing, swelling of the face or throat).
   • Neurological symptoms (e.g., confusion, tremors, or vision disturbances).
4. Post-Treatment Reaction:
   • Fever, headache, muscle pain, or swollen lymph nodes may occur in individuals with heavy infections due to the body’s response to dying parasites.

• Store at room temperature (15°C–25°C) in a dry place, away from direct sunlight.

Additional Information:

• Delivery Time: 12-15 days

• temporarily relieves these symptoms due to hay fever or other upper respiratory allergies:
• runny nose
• sneezing
• itchy, watery eyes
• itching of the nose or throat
• temporarily relieves these symptoms due to the common cold:
• runny nose
• sneezing

• Acute Myeloid Leukemia (AML)

• Acute Lymphoblastic Leukemia (ALL)

• Chronic Myelogenous Leukemia (blast crisis)

• Meningeal leukemia (via intrathecal route)

Cytarabine is converted inside the body to cytarabine triphosphate, which competes with deoxycytidine triphosphate and gets incorporated into DNA. This leads to:

• Inhibition of DNA synthesis

• Cell death, particularly in rapidly dividing cancer cells

• Intravenous (IV), subcutaneous (SC), or intrathecal

• Dosing schedules vary (induction, consolidation, maintenance)

• Bone marrow suppression (↓ WBC, RBC, platelets)

• Fever, nausea, vomiting

• Mouth ulcers, rash

• Neurotoxicity (at high doses)

• Conjunctivitis (in high-dose regimens)

• Non-Hodgkin’s lymphoma

• Hodgkin’s disease

• Multiple myeloma

• Breast and ovarian cancer

• Autoimmune disorders like lupus nephritis, nephrotic syndrome

Cyclophosphamide is a prodrug that gets converted in the liver to active metabolites. These metabolites:

• Alkylate DNA at the N7 position of guanine

• Crosslink DNA strands

• Disrupt replication and transcription

• Induce apoptosis of cancer or immune cells

• Intravenous infusion or oral (other formulations)

• Given in cycles, often with hydration and mesna to prevent bladder toxicity

• Hemorrhagic cystitis

• Myelosuppression

• Nausea, vomiting

• Alopecia (hair loss)

• Risk of infections

• Infertility (long-term use)

• Same indications as Cytalon (AML, ALL, CML in blast crisis, meningeal leukemia)

• Typically used in high-dose regimens (e.g., consolidation phase of AML treatment)

Same as Cytalon — interferes with DNA replication by acting as a fraudulent nucleotide.

• Intravenous infusion

• Often given in cycles under strict monitoring (especially at high doses)

• Higher doses increase risk of:

  • Cerebellar toxicity (ataxia, confusion)

  • Ocular toxicity (needs steroid eye drops prophylactically)

  • Severe myelosuppression

  • Gastrointestinal toxicity

Additional Information:

• Delivery Time: 12-15 days

Emcure Pharmaceuticals Ltd.

• Everolimus 0.25 mg per tablet

• Prevention of organ rejection in kidney and liver transplant patients

• Used in combination with other immunosuppressants like tacrolimus or corticosteroids

• Investigational use in certain oncological indications

Everolimus is an mTOR (mammalian target of rapamycin) inhibitor. It suppresses T-cell activation and proliferation by inhibiting IL-2-mediated signaling, crucial for transplant rejection prevention.

• Commonly started at 0.25 mg to 0.75 mg twice daily

• Adjusted based on trough level monitoring, target levels: 3–8 ng/mL

• Increased risk of infections

• Delayed wound healing

• Hyperlipidemia, hyperglycemia

• Mouth ulcers, cough, diarrhea

• Anemia, leukopenia

• Blister pack of 10 tablets

• Store below 30°C

• Protect from moisture

Intas Pharmaceuticals Ltd.

• Everolimus 0.5 mg per tablet

• Used for organ rejection prophylaxis in renal and liver transplants

• Also prescribed in oncology (e.g., breast, neuroendocrine tumors, RCC) when specified

Identical to other Everolimus brands – inhibits mTOR to prevent T-cell proliferation and reduce immune response.

• Usually prescribed 0.5 mg twice daily

• Regular blood level monitoring required for dose adjustment

• Nausea, stomatitis

• Elevated liver enzymes

• Anemia, fatigue

• Pneumonitis (rare but serious)

• Box of 10 or 30 tablets

• Store at 15–30°C

• Keep in a dry place

Novartis India Ltd.

• Everolimus 0.75 mg per tablet

• FDA-approved for use in:

  • Kidney, liver, and heart transplant recipients

  • Used in combination with cyclosporine and corticosteroids

• Also available in higher doses (e.g., 5 mg, 10 mg) under different brand names for oncology use

• Inhibits mTOR, reducing cytokine-driven T-cell proliferation and immune responses that cause rejection

• Typically initiated at 0.75 mg twice daily in adults

• Adjusted based on therapeutic drug monitoring

• Stomatitis, infections

• Hypertension, proteinuria

• Hypertriglyceridemia, anemia

• Increased risk of malignancy (long-term)

• Blister packs of 10 or 60 tablets

• Store at below 30°C

• Avoid exposure to light and humidity

Additional Information:

• Delivery Time: 12-15 days

• 🏭 Manufacturer: Natco Pharma Limited

• 💊 Formulation: Oral tablets, 1.5 mg strength

• 📋 Indications:

  • Chronic Myeloid Leukemia (CML) – chronic, accelerated, or blast phase (Ph+ positive)

  • Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL)

  • Patients resistant or intolerant to prior therapies (e.g., imatinib)

• 💉 Dosage: Usually 100 mg once or twice daily, depending on disease phase and patient condition

• ⚙️ Pharmacokinetics: Good oral bioavailability, metabolized by CYP3A4 liver enzymes

• ⚠️ Side Effects:

  • Myelosuppression (low blood counts)

  • Fluid retention and edema

  • Diarrhea, headache

  • Risk of QT prolongation (heart rhythm disturbance)

• 🧊 Storage: Store below 25°C, protect from moisture and light

• 🌟 Advantages:

  • Wide availability and strong reputation

  • Cost-effective generic alternative to innovator drug Sprycel

• 🏭 Manufacturer: Intas Pharmaceuticals Ltd

• 💊 Formulation: Oral tablets, 1.5 mg strength

• 📋 Indications: Same as Rasbelon (CML and Ph+ ALL treatment)

• 💉 Dosage: As per physician’s guidance, following standard dasatinib dosing protocols

• ⚙️ Pharmacokinetics & Side Effects: Similar to Rasbelon due to same active ingredient

• 🧊 Storage: Store in a cool, dry place away from sunlight

• 🌟 Advantages:

  • Reputable manufacturer with a strong generic portfolio

  • Competitive pricing, good alternative choice

Additional Information:

• Delivery Time: 12-15 days

Generic Name: Fluconazole 500 mg
Drug Class: Triazole antifungal
Form: Tablet
Common Manufacturer: American Remedies

• Each tablet contains:
  ‣ Fluconazole IP 500 mg

Robican (Fluconazole 500 mg) is used to treat systemic and severe fungal infections, including:

• Systemic candidiasis

• Cryptococcal meningitis

• Oropharyngeal and esophageal candidiasis

• Disseminated or deep organ fungal infections

• Fungal infections in immunocompromised patients (e.g., HIV/AIDS, post-chemo)

• Sometimes used in resistant or recurrent vaginal candidiasis (off-label)

• Fluconazole inhibits fungal cytochrome P450 enzyme (lanosterol 14α-demethylase)

• This blocks ergosterol synthesis, which is essential for fungal cell membrane integrity

• Causes fungal cell death by disrupting membrane permeability

• 500 mg once daily, depending on severity and site of infection

• Duration: Varies from 7 days to several weeks

• Must be taken exactly as prescribed — overdosing or premature stopping can lead to resistance

• Headache

• Nausea

• Abdominal pain

• Skin rash

• Liver enzyme elevation

• Taste changes

• Fatigue feeling

• Diarrhea

• Hepatotoxicity (liver injury)

• QT prolongation

• Stevens-Johnson syndrome (severe rash)

• Should be avoided during pregnancy unless necessary

• Drug interactions: Caution with warfarin, phenytoin, statins, and oral hypoglycemics

• Store at room temperature, below 25°C

• Protect from moisture and light

• Shelf life: ✅ 36 months (3 years) from date of manufacture

Additional Information:

• Delivery Time: 12-15 days

Dactinomycin (also known as Actinomycin D)

Dacilon

Lyophilized powder for reconstitution and intravenous injection

0.5 mg per vial

Celon Laboratories Ltd., India

Dacilon is a chemotherapy medication used to treat a variety of cancers, including:

• Wilms’ tumor (childhood kidney cancer)

• Rhabdomyosarcoma (cancer of skeletal muscle)

• Ewing’s sarcoma (bone cancer)

• Gestational trophoblastic neoplasia (pregnancy-related cancer)

• Testicular cancer

• Other pediatric and solid tumors

Dacilon (Dactinomycin) works by:

• Binding to DNA

• Inhibiting RNA synthesis

• Blocking protein production

• Ultimately stopping cancer cell growth and replication

Because it targets fast-dividing cells, it also affects some healthy cells, leading to side effects.

• Route: Intravenous (IV) only

• Administration: Must be done under the supervision of a trained medical professional

• Dosage: Varies based on patient weight, body surface area (BSA), and cancer type

• Often used in combination with other chemotherapy agents

• Nausea and vomiting

• Diarrhea

• Loss of appetite

• Mouth sores (stomatitis)

• Fatigue

• Hair loss

• Skin reactions at the injection site

• Bone marrow suppression (low white/red blood cells)

• Increased risk of infections

• Liver toxicity

• Allergic reactions

• Radiation recall (inflammation of skin in previously irradiated areas)

• Not safe during pregnancy – may cause birth defects

• Avoid during breastfeeding

• Use cautiously in patients with liver or kidney impairment

• Avoid use if there's a current active infection

• Temperature: 2°C to 8°C (Refrigerated)

• Protect from: Light and moisture

• Do not freeze

• Store in original packaging until ready for use

• 24 months from the date of manufacture, if stored properly

Additional Information:

• Delivery Time: 12-15 days

Temporarily relieving pain of the mouth, throat, or nose, and certain parts of the digestive tract. It may also be used for other conditions as determined by your doctor.

Xylocaine solution is a local anesthetic. It works by preventing nerves from transmitting painful impulses to the brain.