Maxwell Enterprises

Exporter & Dropshipper Of Sifasi Injection at lowest cost.

Leveraging upon our vast industry experience, we are engaged in trading, exporting and supplying an excellent range of Sifasi Injections. This injection is processed by our vendors using best quality chemical compound and latest technology. To assure its quality and effectiveness, this Sifasi Injections is strictly tested on varied quality parameters. We offer this injection at market leading prices within promised time frame.

Exporter & Dropshipper Of Zyhcg Injection at lowest cost.

We are offering best treatment solution to all patrons by providing Zyhcg Injection. This injection is supplied to the patrons in sealed packing and is only for single use. Laboratory experts have used best non reactive chemical for the manufacturing of this injection. It must be injected into muscle. It also induces ovulation within 38 to 40 hours.

Features:
* Sealed packing
* Sharp end
* Longer shelf life

💉 Mibor 2mg Injection

• Generic Name: Bortezomib

• Brand Name: Mibor

• Manufacturer: Celon Laboratories Ltd

• Strength: 2 mg

• Form: Lyophilized Powder for Injection

✅ Indications:

• Multiple Myeloma (a type of blood cancer)

• Mantle Cell Lymphoma

⚙️ Mechanism of Action:

Bortezomib is a proteasome inhibitor. It works by blocking the action of proteasomes (cellular complexes that break down proteins). By inhibiting proteasomes, Bortezomib causes an accumulation of proteins in cancer cells, leading to their death.

💡 Dosage & Administration:

• Administered intravenously (IV) or subcutaneously (SC)

• Given in cycles, often in combination with other chemotherapy agents

• Dosage adjusted based on patient response and tolerability

⚠️ Side Effects:

• Common: Nausea, diarrhea, fatigue, low blood counts (anemia, neutropenia), peripheral neuropathy (nerve pain)

• Serious: Cardiac issues, lung problems, liver enzyme elevation

❗ Precautions:

• Monitor liver and kidney function

• Regular blood tests needed during treatment

• Avoid use during pregnancy and breastfeeding

💉 Bortecad 2.5mg Injection

• Generic Name: Bortezomib

• Brand Name: Bortecad

• Manufacturer: Cadila Pharmaceuticals Ltd

• Strength: 2.5 mg

• Form: Lyophilized Powder for Injection

✅ Indications:

• Multiple Myeloma

• Mantle Cell Lymphoma

⚙️ Mechanism of Action:

Functions similarly as a proteasome inhibitor, disrupting normal protein breakdown in cells, leading to stress and eventual death of cancerous cells.

💡 Dosage & Administration:

• Administered via IV or SC routes

• Given on specific days in 21- or 28-day cycles

• Adjust dose based on response, blood count, and side effects

⚠️ Side Effects:

• Nausea, vomiting, loss of appetite, neuropathy, low platelet counts

• More severe effects include breathing problems and liver toxicity

❗ Precautions:

• Careful monitoring of neurological symptoms and blood counts

• Use with caution in older adults or those with preexisting heart/lung issues

💉 Borviz 3.5mg Injection

• Generic Name: Bortezomib

• Brand Name: Borviz

• Manufacturer: Intas Pharmaceuticals Ltd

• Strength: 3.5 mg

• Form: Lyophilized Powder for Injection

✅ Indications:

• Multiple Myeloma

• Mantle Cell Lymphoma

⚙️ Mechanism of Action:

Same mechanism as others: proteasome inhibition, leading to apoptosis (cell death) of malignant cells.

💡 Dosage & Administration:

• Standard recommended dose: 1.3 mg/m² body surface area

• Administered via IV or SC injection, usually twice weekly during induction phase

• Dose modified in case of side effects or low blood counts

⚠️ Side Effects:

• Neuropathy, tiredness, dizziness, anemia, low WBC/platelets

❗ Precautions:

• Baseline ECG, liver function, and blood cell counts advised

• Monitor for signs of peripheral neuropathy and infections

Additional Information:

• Delivery Time: 12-15 days

 Celtere 80 mg Generic Name:

Docetaxel

 Drug Class:

Antineoplastic agent — Taxane group

 Indications:

• Breast cancer

• Non-small cell lung cancer (NSCLC)

• Prostate cancer

• Gastric cancer

• Head and neck cancers

 Mechanism of Action:

• Inhibits microtubule depolymerization

• Prevents cell division (mitosis), leading to apoptosis (cell death) in cancer cells

 Dosage & Administration:

• Usually administered via intravenous infusion

• 80 mg dose is considered a moderate dose for some chemotherapy regimens

• Dose and cycle depend on cancer type and patient condition

 Side Effects:

• Neutropenia (low white blood cell count)

• Peripheral neuropathy (numbness, tingling)

• Fluid retention and edema

• Nausea, vomiting

• Hair loss (alopecia)

 Storage:

• Store vials refrigerated at 2°C to 8°C

• Protect from light and freezing

 Docetere 20 mg Generic Name:

Docetaxel

 Drug Class:

Antineoplastic agent — Taxane group

 Indications:

• Used primarily for dose adjustments or in patients requiring lower doses due to frailty or toxicity risks

• Can be part of chemotherapy protocols needing gradual escalation

 Mechanism of Action:

Same as Celtere (docetaxel) — disrupts microtubule function leading to cancer cell death

 Dosage & Administration:

• IV infusion

• 20 mg dose for specific dosing needs or initial cycles

 Side Effects:

• Similar to higher doses but generally less severe due to lower amount administered

 Storage:

• Refrigerate at 2–8°C, protect from light

 Docax 120 mg Generic Name:

Docetaxel

 Drug Class:

Antineoplastic agent — Taxane group

 Indications:

• Standard dose used in many cancers, including:

  • Prostate cancer

  • Breast cancer

  • NSCLC

  • Gastric cancer

 Mechanism of Action:

• Same as above — inhibits microtubule depolymerization causing apoptosis in cancer cells

 Dosage & Administration:

• IV infusion

• 120 mg dose typically used for full standard chemotherapy cycles (e.g., every 3 weeks)

 Side Effects:

• More pronounced than lower doses:

  • Severe neutropenia

  • Fluid retention and edema (may require corticosteroid premedication)

  • Peripheral neuropathy

  • Nausea and vomiting

 Storage:

• Store refrigerated at 2–8°C

• Protect from light and freezing

Additional Information:

• Delivery Time: 12-15 days

 Fludabine 10 mg Manufacturer

Various manufacturers (specific brand info may vary).

 Composition

Each tablet or vial contains Fludarabine Phosphate 10 mg.

 Indications

• Used in the treatment of hematologic malignancies, especially chronic lymphocytic leukemia (CLL).

• May be used in lower doses as part of combination chemotherapy regimens.

• Sometimes used for patients who require dose adjustments due to tolerance or specific treatment protocols.

 Mechanism of Action

Fludarabine is a purine analog that interferes with DNA synthesis by inhibiting DNA polymerase, ribonucleotide reductase, and DNA primase, leading to inhibition of DNA replication and cell death in cancer cells.

 Dosage & Administration

• Dose varies based on disease and patient condition.

• Usually administered intravenously but oral forms may be available.

• Lower doses (like 10 mg) may be given for specific regimens or tapering.

 Side Effects

• Myelosuppression (low blood counts), infections, anemia, thrombocytopenia.

• Fatigue, nausea, fever, neurotoxicity in some cases.

 Packaging

• Typically available as tablets or injectable solution depending on formulation.

 Storage

• Store as per manufacturer’s guidelines, usually in a cool, dry place.

 Fludacel 50 mg Manufacturer

Popular brands like Natco Pharma and others.

 Composition

Each vial or tablet contains Fludarabine Phosphate 50 mg.

 Indications

• Primarily used for treatment of chronic lymphocytic leukemia (CLL) and other blood cancers.

• Often used as a standard dose in chemotherapy regimens for hematologic malignancies.

 Mechanism of Action

Same as Fludabine 10 mg: Fludarabine inhibits DNA synthesis in rapidly dividing malignant cells, causing apoptosis.

 Dosage & Administration

• Commonly administered intravenously as 50 mg per dose.

• Dosage schedules depend on treatment protocol and patient condition.

 Side Effects

• Similar to 10 mg dose but may be more pronounced due to higher dosage: bone marrow suppression, risk of infections, nausea, fatigue.

 Packaging

• Available in vials for injection or tablets, typically in packs suitable for chemotherapy cycles.

 Storage

• Store refrigerated or as per specific product instructions, protected from moisture and light.

Additional Information:

• Delivery Time: 12-15 days

 Fluracil 250 mg InjectionManufacturer

• Zydus Cadila, India

Composition

• Each vial contains Fluorouracil 250 mg in 5 mL solution.

Indications

• Treatment of various cancers including colorectal, breast, gastric, pancreatic, head and neck, esophageal, anal, and bladder cancers.

• Used alone or as part of combination chemotherapy.

Mechanism of Action

• Fluorouracil is an antimetabolite that inhibits DNA and RNA synthesis in rapidly dividing cancer cells, leading to cell death.

Dosage & Administration

• Administered intravenously, usually as bolus or infusion.

• Dosage varies according to cancer type, treatment regimen, and patient condition.

Side Effects

• Common: nausea, vomiting, diarrhea, mouth sores, hair loss, fatigue, low blood counts.

• Serious: cardiotoxicity, neurologic toxicity, infections, hand-foot syndrome, mucositis.

Storage

• Store in a cool, dry place away from light.

• Do not freeze.

 5-Flucel 500 mg InjectionManufacturer

• Celon Laboratories Ltd., India

Composition

• Each vial contains Fluorouracil 500 mg in 10 mL solution.

Indications

• Same as Fluracil 250 mg: colorectal, breast, gastric, pancreatic, head and neck, esophageal, anal, and bladder cancers.

• Used intravenously, often in combination chemotherapy.

Mechanism of Action

• Same as Fluracil 250 mg: inhibits DNA and RNA synthesis in cancer cells causing cell death.

Dosage & Administration

• Intravenous administration with dosage adjusted to patient needs.

• Higher dose suitable for more intensive treatment regimens.

Side Effects

• Similar to Fluracil 250 mg: gastrointestinal upset, mucositis, fatigue, hair loss, bone marrow suppression.

• Higher doses may increase risk of severe side effects.

Storage

• Store in a cool, dry place away from light.

• Do not freeze.

Additional Information:

• Delivery Time: 12-15 days

 What Is Erbitux (Cetuximab)?

• Erbitux is a chimeric monoclonal antibody targeting the epidermal growth factor receptor (EGFR).

• Used in KRAS wild-type metastatic colorectal cancer (mCRC) and head & neck squamous cell carcinoma (HNSCC).

• Works by blocking EGFR signaling, which slows tumor growth and promotes apoptosis.

 1. Erbitux 100 mg Composition:

• Each vial contains 100 mg of cetuximab in 20 mL solution (5 mg/mL).

 Formulation:

• Clear, colorless to pale yellow solution

• For intravenous infusion after dilution

 Usage:

• Used when lower doses are required (e.g., low BSA or pediatric patients).

• Can be used for dose adjustments or combination with 500 mg vial to reach precise dosing.

 Common Indications:

• Metastatic colorectal cancer (with FOLFIRI or alone)

• Recurrent/metastatic head & neck cancers (with radiation or platinum-based chemo)

 Dosing Example:

• Loading dose: 400 mg/m²

• Maintenance dose: 250 mg/m² weekly or 500 mg/m² biweekly

 Limitations:

• Less convenient for high doses (requires 4–5 vials for 400–500 mg dose)

• More time-consuming for preparation

 2. Erbitux 500 mg Composition:

• Each vial contains 500 mg of cetuximab in 100 mL solution (5 mg/mL).

 Formulation:

• Ready-to-infuse solution

• Also for IV infusion after dilution

 Usage:

• Preferred in most adult dosing regimens

• Supports biweekly dosing (500 mg/m² every 2 weeks), which is becoming standard

• Improves infusion convenience and reduces waste

 Common Indications:

• Same as 100 mg version, but widely used for standard adult treatment protocols

 Advantages:

• Fewer vials per dose = faster prep

• Reduces volume of excipients per dose

• Lower cost per mg compared to 100 mg in some markets

Additional Information:

• Delivery Time: 12-15 days

1.  Endoxan N 500 mg Generic Name: Cyclophosphamide Brand Name: Endoxan N Strength: 500 mg Form: Oral tablets or injectable solution Indications:

• Used in chemotherapy for:

  • Breast cancer

  • Lymphomas

  • Leukemias

  • Multiple myeloma

  • Ovarian and lung cancers

• Also used as an immunosuppressant in autoimmune diseases (e.g., lupus nephritis, vasculitis)

 Mechanism of Action:

• Alkylating agent causing DNA crosslinking

• Interferes with DNA replication and cell division

• Leads to apoptosis, mainly affecting rapidly dividing cancer and immune cells

 Administration:

• Oral or intravenous

• Dosage varies by protocol and disease

 Common Side Effects:

• Myelosuppression (low blood counts)

• Nausea and vomiting

• Hair loss

• Hemorrhagic cystitis (bladder irritation)

• Increased infection risk

2.  Cyphos 200 mg Generic Name: Cyclophosphamide Strength: 200 mg Form: Oral tablets or injection Indications:

• Same as Endoxan N but often used for dose titration or in protocols requiring lower doses

3.  Phoxelon 1000 mg Active Ingredient: This one is ambiguous without more info. If this is Phosphoethanolamine or a different compound, please clarify. It is not a standard chemotherapy drug like cyclophosphamide.

• If you meant Ifosfamide or another alkylating agent, please confirm.

• Otherwise, I cannot provide a reliable detailed description without the exact active ingredient.

4.  Cycloxan 50 mg Generic Name: Cyclophosphamide Strength: 50 mg Form: Oral tablets Indications:

• Used in low-dose protocols for cancers or autoimmune diseases

• May be used for maintenance therapy or dose-adjusted treatments

 General Storage for Cyclophosphamide Products:

• Store at 20°C to 25°C (room temperature)

• Protect from moisture and light

• Keep out of reach of children

Additional Information:

• Delivery Time: 12-15 days

 Darzalex (Daratumumab) 100 mg and 400 mg Generic Name:

Daratumumab

 Brand:

Darzalex (by Janssen Pharmaceuticals)

 Formulation & Strengths:

• 100 mg vial — used for precise dose adjustments or in patients requiring smaller doses.

• 400 mg vial — preferred for standard dosing in most adult patients, reducing the number of vials needed.

 Indications:

Darzalex is used to treat multiple myeloma, including:

• Newly diagnosed multiple myeloma (in combination with other agents or as monotherapy)

• Relapsed or refractory multiple myeloma

• Certain types of amyloidosis

 Mechanism of Action:

Daratumumab is a monoclonal antibody that binds to the CD38 protein found on myeloma cells. This binding:

• Triggers immune system attacks on the cancer cells

• Causes direct cancer cell death through multiple mechanisms (complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, apoptosis)

 Dosage and Administration:

• Dosage is usually based on 16 mg/kg of body weight.

• Darzalex is given as an intravenous infusion (sometimes subcutaneous forms are available).

• The number of vials used depends on patient weight and vial strength.

• The 400 mg vial is preferred for adults to minimize the number of vials per dose and reduce infusion time.

 Side Effects:

• Infusion-related reactions (fever, chills, cough)

• Fatigue

• Nausea

• Diarrhea

• Low blood counts (neutropenia, anemia)

• Infections (due to immunosuppression)

• Respiratory infections

 Storage:

• Store refrigerated at 2°C to 8°C (36°F to 46°F).

• Protect from light.

• Do not freeze.

• Keep in original vial until ready to use.

Additional Information:

• Delivery Time: 12-15 days

 Decintas 30 mg Generic Name:

Decitabine

 Drug Class:

Hypomethylating agent (a cytidine analog)

 Indications:

• Primarily used for myelodysplastic syndromes (MDS)

• Also used in some protocols for acute myeloid leukemia (AML), especially in older adults or those unfit for intensive chemotherapy

 Mechanism of Action:

• Incorporates into DNA and inhibits DNA methyltransferase

• Leads to hypomethylation of DNA and reactivation of tumor suppressor genes, resulting in slowed cancer cell growth or cell death

 Dosage & Administration:

• IV infusion only

• 30 mg vial used in dose-adjusted or low-body surface area (BSA) patients

• Usually administered once daily for 5 consecutive days in a 28-day cycle

 Side Effects:

• Neutropenia, thrombocytopenia, anemia

• Fatigue, nausea, fever

• Increased risk of infection

• Liver enzyme elevation

 Storage:

• Store refrigerated at 2°C to 8°C

• Protect from light

• Use immediately after reconstitution or per institutional protocol

 Decitex 50 mg Generic Name:

Decitabine

 Drug Class:

Hypomethylating agent

 Indications:

• Approved for treatment of MDS

• Also commonly used off-label for AML, especially in older patients or those not eligible for intensive therapy

 Mechanism of Action:

• Similar to Decintas—acts on DNA methylation

• Promotes differentiation or apoptosis in abnormal hematopoietic cells

 Dosage & Administration:

• IV infusion over 1–3 hours

• 50 mg vial aligns with standard dosing (20 mg/m²/day × 5 days)

• Typically preferred in most treatment regimens due to fewer vials per cycle

 Side Effects:

• Bone marrow suppression (low WBCs, RBCs, platelets)

• Gastrointestinal discomfort (nausea, vomiting)

• Fever, fatigue

• Rare: hepatic toxicity, tumor lysis syndrome

 Storage:

• Store refrigerated (2°C to 8°C)

• Use immediately after reconstitution or per local protocol

Additional Information:

• Delivery Time: 12-15 days

💉 1. Filcad P 6 mg 🔹 Generic Name: Pegfilgrastim 🔹 Brand: Filcad P 🔹 Strength: 6 mg/0.6 mL prefilled syringe 🔹 Manufacturer: Intas Pharmaceuticals Ltd. ✅ Indications:

• Prevention of chemotherapy-induced neutropenia

• Reduces the duration of neutropenia and incidence of febrile neutropenia in cancer patients undergoing cytotoxic chemotherapy

• Used in non-myeloid malignancies

💊 Mechanism of Action:

• Pegfilgrastim is a pegylated form of filgrastim, a granulocyte colony-stimulating factor (G-CSF) analog

• Stimulates the production, maturation, and activation of neutrophils in the bone marrow

• Pegylation extends the half-life, allowing single-dose per chemotherapy cycle administration

💉 Administration:

• Given as a single subcutaneous injection once per chemotherapy cycle

• Typically administered 24 hours after chemotherapy

⚠️ Side Effects:

• Bone pain (most common)

• Injection site reactions

• Headache, fatigue, fever

• Rare: splenic rupture, acute respiratory distress syndrome

📦 Storage:

• Store refrigerated at 2–8°C

• Do not freeze

• Protect from light

💉 2. Peg Grafeel 6 mg 🔹 Generic Name: Pegfilgrastim 🔹 Brand: Peg Grafeel 🔹 Strength: 6 mg/0.6 mL prefilled syringe 🔹 Manufacturer: Intas Pharmaceuticals Ltd. ✅ Indications:

• Same as Filcad P: prevention and treatment of neutropenia during chemotherapy

• Used in various solid tumors and hematologic malignancies

💊 Mechanism of Action:

• Identical to Filcad P, stimulates neutrophil production

• Long-acting due to pegylation, reducing injection frequency

💉 Administration:

• Single SC injection per chemotherapy cycle, ideally 24 hours post-chemo

⚠️ Side Effects:

• Similar profile: bone pain, injection site swelling, fever, fatigue

• Rare but serious effects include splenic enlargement

📦 Storage:

• Refrigerate at 2–8°C

• Avoid freezing and light exposure

💉 3. Pegasta 6 mg 🔹 Generic Name: Pegfilgrastim 🔹 Brand: Pegasta 🔹 Strength: 6 mg/0.6 mL prefilled syringe 🔹 Manufacturer: Intas Pharmaceuticals Ltd. ✅ Indications:

• Prevention of chemotherapy-induced neutropenia

• Shortens neutropenia duration and febrile episodes in cancer patients

💊 Mechanism of Action:

• Stimulates neutrophil production by binding G-CSF receptors

• Pegylation prolongs half-life, enabling once-per-cycle dosing

💉 Administration:

• Single SC injection per chemo cycle, usually 24 hours after chemotherapy

⚠️ Side Effects:

• Bone pain, headache, fever, injection site redness

• Rare adverse events include splenic rupture and allergic reactions

📦 Storage:

• Store refrigerated at 2–8°C

• Do not freeze

• Protect from light

Additional Information:

• Delivery Time: 12-15 days

💉 Tepapro 15 mg Injection

• Generic Name: Thiotepa

• Manufacturer: Emcure Pharmaceuticals Ltd

• Formulation: Lyophilized Powder for Injection

• Strength: 15 mg/vial

✅ Indications

• Preparation for hematopoietic stem cell transplantation (HSCT)

• Treatment of:

  • Breast cancer

  • Ovarian cancer

  • Bladder cancer

  • Neoplastic diseases involving serosal cavities

  • Malignant effusions caused by tumors

⚙️ Mechanism of Action

Tepapro (Thiotepa) is an alkylating agent. It works by interfering with the DNA replication process, causing cross-linking of DNA strands, which leads to the death of rapidly growing cancer cells.

💊 Dosage & Administration

• Given as an intravenous infusion under medical supervision.

• Dosage is individualized based on patient’s body surface area, condition, and treatment protocol.

⚠️ Common Side Effects

• Neutropenia (low white blood cells)

• Anemia

• Thrombocytopenia (low platelets)

• Mucosal inflammation

• Diarrhea

• Rash

• Liver enzyme elevation

• Hemorrhage

🧊 Storage

• Store below 30°C

• Protect from light and moisture

💉 Thiopta 15 mg Injection

• Generic Name: Thiotepa

• Manufacturer: Samarth Life Sciences Pvt. Ltd

• Formulation: Lyophilized Powder for Injection

• Strength: 15 mg/vial

✅ Indications

• Part of conditioning regimen for HSCT

• Used in the treatment of:

  • Breast cancer

  • Ovarian cancer

  • Bladder cancer

  • Serosal cavity involvement with malignancy

  • Malignant pleural/peritoneal effusions

⚙️ Mechanism of Action

Thiopta contains Thiotepa, which is an alkylating chemotherapeutic agent. It disrupts DNA function by forming cross-links between DNA strands, preventing cell division and resulting in cancer cell death.

💊 Dosage & Administration

• Administered via intravenous infusion

• Requires dilution and reconstitution before use

• Only under the supervision of qualified oncology personnel

⚠️ Common Side Effects

• Nausea and vomiting

• Loss of appetite

• Abdominal pain

• Injection site discomfort

• Fatigue

• Hair thinning

• Mucositis

🧊 Storage

• Store between 2°C and 8°C

• Protect from light

Additional Information:

• Delivery Time: 12-15 days

💉 Biomab EGFR 50 mg 1. Drug Overview

• Generic Name: Cetuximab

• Brand Name: Biomab EGFR

• Drug Class: Monoclonal antibody (targeted therapy)

• Mechanism of Action:
  Cetuximab is a chimeric (mouse/human) monoclonal antibody that binds specifically to the extracellular domain of the epidermal growth factor receptor (EGFR). By blocking EGFR activation, it inhibits downstream signaling pathways involved in cancer cell proliferation, survival, angiogenesis, and metastasis. This results in the suppression of tumor growth.

2. Indications

• Colorectal Cancer:
  Used in combination with chemotherapy for treatment of metastatic colorectal cancer (mCRC) with wild-type KRAS gene (EGFR-positive).

• Head and Neck Squamous Cell Carcinoma (HNSCC):
  Used as a single agent or with radiation therapy in locally or regionally advanced squamous cell carcinoma of the head and neck.

• May be used in other cancers expressing EGFR as per oncologist discretion.

3. Dosage Form

• Form: Intravenous infusion

• Strength: 50 mg vial (usually comes in vials of 50 mg, 100 mg, or 200 mg for preparation)

4. Dosage and Administration

• Initial Dose: Typically 400 mg/m² infused over 2 hours.

• Maintenance Dose: 250 mg/m² infused weekly over 1 hour.

• Dosage and schedule may vary based on cancer type, patient tolerance, and treatment protocol.

• Requires dilution and administration via intravenous infusion by a healthcare professional.

• Pre-medication with antihistamines (e.g., diphenhydramine) and corticosteroids may be given to reduce infusion-related reactions.

5. Pharmacokinetics

• Half-life: Approximately 112 hours (about 4.5 days) after multiple doses.

• Clearance is dose-dependent and decreases with repeated dosing.

• Metabolized via protein degradation pathways.

6. Side Effects

• Common:

  • Acneiform rash (skin rash resembling acne, often a marker of efficacy)

  • Infusion-related reactions (fever, chills, hypotension)

  • Fatigue

  • Diarrhea

  • Nausea and vomiting

• Serious:

  • Severe infusion reactions (anaphylaxis)

  • Electrolyte abnormalities (hypomagnesemia)

  • Cardiac arrest (rare)

  • Interstitial lung disease (rare)

7. Warnings and Precautions

• Monitor closely for infusion reactions during and after infusion.

• Assess magnesium, potassium, and calcium levels regularly during therapy.

• Discontinue therapy for severe or life-threatening reactions.

• Use caution in patients with pre-existing cardiac conditions.

8. Storage

• Store vials refrigerated at 2–8°C (do not freeze).

• Protect from light.

• Use within specified time after reconstitution/preparation.

Additional Information:

• Delivery Time: 12-15 days

💊 Emgrast M 500 mcg (Filgrastim + Methylcobalamin) 1. Composition

• Filgrastim 500 mcg

  • A recombinant human Granulocyte Colony-Stimulating Factor (G-CSF)

• Methylcobalamin (Vitamin B12)

  • Active form of Vitamin B12, essential for nerve health and hematopoiesis

2. Pharmacological Class

• Filgrastim: Hematopoietic Growth Factor

• Methylcobalamin: Vitamin Supplement

3. Mechanism of Action

• Filgrastim:
  Stimulates the bone marrow to increase production of neutrophils (a type of white blood cell), helping to fight infection and recover neutrophil count after chemotherapy or bone marrow suppression.

• Methylcobalamin:
  Supports DNA synthesis and red blood cell formation, and improves nerve regeneration and function.

4. Indications

• Prevention and treatment of neutropenia caused by chemotherapy or bone marrow transplantation

• Treatment of febrile neutropenia

• Support in patients with aplastic anemia or other bone marrow disorders

• Used in peripheral neuropathy or vitamin B12 deficiency states due to methylcobalamin component

5. Dosage and Administration

• Route: Subcutaneous injection (most common) or intravenous infusion

• Filgrastim dose: Typically 5 mcg/kg/day, adjusted per patient condition

• Methylcobalamin dose: 500 mcg per injection as per formulation

• Duration varies according to clinical response and physician’s guidance

6. Side Effects

• Bone pain (common with Filgrastim)

• Injection site reactions

• Headache, fatigue

• Rare: Splenic rupture, allergic reactions

• Methylcobalamin generally well tolerated

7. Storage

• Store refrigerated at 2–8°C

• Protect from light

• Do not freeze

8. Special Precautions

• Monitor complete blood counts regularly during therapy

• Use cautiously in patients with sickle cell disease or other hematologic disorders

• Not for use in patients with hypersensitivity to any components

Additional Information:

• Delivery Time: 12-15 days

💊 Topotec 2.5 mg

Generic Name: Topotecan
Formulation: Injectable solution or capsules (depending on brand)
Strength: 2.5 mg (usually vial strength for injection)
Drug Class: Topoisomerase I inhibitor (chemotherapy agent)

✅ Indications

• Treatment of small cell lung cancer (SCLC)

• Treatment of ovarian cancer after failure of first-line chemotherapy

• Sometimes used in cervical cancer and other solid tumors

⚙️ Mechanism of Action

Topotecan inhibits topoisomerase I, an enzyme responsible for relieving DNA supercoiling during replication. By stabilizing the complex between topoisomerase I and DNA, it causes DNA strand breaks, leading to cancer cell death.

💊 Dosage & Administration

• Administered intravenously over 30 minutes, typically daily for 5 consecutive days every 21 days.

• Dosage adjusted based on body surface area and patient tolerance.

⚠️ Common Side Effects

• Myelosuppression (especially neutropenia, anemia, thrombocytopenia)

• Nausea and vomiting

• Fatigue and weakness

• Diarrhea

• Hair thinning or loss

🧊 Storage

• Store at 2°C to 8°C (refrigerated)

• Protect from light

💊 Topowin

Generic Name: Topotecan (likely same active ingredient)
Formulation: Usually injectable or oral form (brand-specific)
Strength: Variable, commonly available in 2.5 mg vials for injection

✅ Indications

• Same as Topotec (used in ovarian, small cell lung, and cervical cancers)

⚙️ Mechanism of Action

• Identical to Topotec, as it contains the same active ingredient, Topotecan.

💊 Dosage & Administration

• Similar dosing regimen to Topotec.

• Administered intravenously or orally as per protocol.

⚠️ Side Effects

• Comparable safety profile to Topotec.

• Monitor blood counts closely.

🧊 Storage

• Refrigerated storage recommended.

• Follow manufacturer guidelines.

📊 Usage & Preference

• Topotec 2.5 mg is more widely recognized and prescribed because it is a well-established brand or generic.

• Topowin may be a brand or alternative generic; usage depends on regional availability and hospital preference.

Additional Information:

• Delivery Time: 12-15 days

What is BIOMAb EGFR

BIOMAb EGFR, a humanized monoclonal antibody falls under a class of cancer treatment option known as targeted therapy.

Targeted cancer therapies interfere with cancer cell growth and division in different ways and at various points during the development, growth, and spread of cancer. They target molecules specific to cancer cells and prevent the cancerous cells from growing, dividing and spreading uncontrollably.

BIOMAb EGFR (Nimotuzumab) is also known by the brand names Theracim, Theraloc, etc., in different countries where it is approved.

BIOMAb EGFR is currently approved for treatment of head and neck cancers in India, Cuba, Argentina, Colombia, Ivory Coast, Gabon, Ukraine, Peru, Vietnam and Sri Lanka; for glioma (pediatric and adult) in Cuba, Argentina, the Philippines, Myanmar, Mexico, Indonesia, Switzerland, Vietnam, Brazil and Ukraine; for nasopharyngeal cancer (a type of head and neck cancer) in China. It has been granted orphan drug status for Glioma in the USA and for Glioma and pancreatic cancer in Europe. A number of clinical trials are being conducted worldwide to evaluate the efficacy of this molecule in various other indications also like lung cancer, pancreatic cancer, cervical cancer etc

How does BIOMAb EGFR work?

BIOMAb EGFR targets the epidermal growth factor receptor (EGFR) present on the cell surface. The binding of certain growth factors to this receptor starts a series of events that are essential for cell growth, differentiation, and survival (both normal and cancerous). In cancerous cells there is an over expression of EGFR leading to uncontrolled cell growth, proliferation, survival and creation of new blood vessels. A very high level of EGFR is seen in many solid tumors and has been associated with poor treatment outcomes. BIOMAb EGFR binds to the site on EGFR where the growth factors are supposed to bind and thus prevents cancer cells from proliferating, making new blood vessels and evading death. BIOMAb EGFR also helps the body's immune system in recognizing the cancerous cells and fighting against them.

Side effects of BIOMAb EGFR?

Based on the experience of thousands of patients, BIOMAb EGFR remains to be the unique monoclonal antibody of its class that has rarely exhibited any severe skin rashes till date.

Studies conducted worldwide prove that BIOMAb EGFR has a very good safety profile. In an Indian study of 92 patients with head and neck cancer, there have not been any incidences of severe skin rashes, hypomagnesaemia (low magnesium count) and other classical EGFR inhibition related side effects.

In over 9,000 patients worldwide and over 3000 patients treated in India, there have rarely been any toxicities which are usually frequently reported with other EGFR targeting agents. The common side effects that have been observed with BIOMAb EGFR are chills, rigors, nausea and very minor rashes.

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Epoetin beta is a synthetic, recombinant form of erythropoietin. It stimulates erythropoiesis (increases red blood cell levels) and is used to treat anemia, commonly associated with chronic renal failure and cancer chemotherapy.

Mahesh medicos is generic medicine wholesaler from india.
For more inquiry please mail us or contact us at our email id/telephone.

We are looking for foreign enquiries only.

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