Maxwell Enterprises

DUOLIN ROTACAPS are indicated for use in patients with COPD, who are on a regular bronchodilator, or who continue to have evidence of bronchospasm and require a second bronchodilator.

🔹 1. Alimta (100 mg)

• Generic Name: Pemetrexed disodium

• Manufacturer: Eli Lilly and Company (USA)

• Formulation: Lyophilized powder for injection (100 mg or 500 mg vials)

• Indications:

  • Malignant pleural mesothelioma (in combination with cisplatin)

  • Non-small cell lung cancer (non-squamous)

• Approval:

  • FDA approved in 2004

  • Also approved by EMA, TGA, and multiple global regulatory bodies

• Status: Innovator/original brand

• Strengths:

  • Extensive clinical trial data

  • Proven efficacy and safety profile

  • Still preferred in countries with high healthcare budgets or private insurance

• Limitations:

  • High cost, often limiting access in low- and middle-income countries

🔹 2. Pemgem (500 mg)

• Generic Name: Pemetrexed disodium

• Manufacturer: Dr. Reddy’s Laboratories (India)

• Formulation: Lyophilized powder for injection (typically available in 500 mg vial)

• Indications:

  • Same as Alimta (NSCLC, mesothelioma)

• Status: Generic version

• Strengths:

  • Widely used in Indian hospitals

  • Cost-effective alternative to Alimta

  • Manufactured by a globally trusted pharma company

  • Exported to various developing countries

• Limitations:

  • Fewer clinical trials published independently on the brand version

  • Availability may be limited outside India unless imported

🔹 3. Pexitas (500 mg)

• Generic Name: Pemetrexed disodium

• Manufacturer: Hetero Labs Ltd. (India)

• Formulation: Lyophilized powder for injection (500 mg)

• Indications:

  • NSCLC, mesothelioma

• Status: Generic version

• Strengths:

  • Produced by a large Indian pharmaceutical exporter

  • WHO GMP certified facilities

  • Competitive pricing for bulk hospital procurement

• Limitations:

  • Less internationally known compared to Pemgem or Alimta

  • More commonly found in public tenders and institutional sales

🔹 4. Pemeplast (100 mg)

• Generic Name: Pemetrexed disodium

• Manufacturer: Zydus Lifesciences (India)

• Formulation: Lyophilized powder for injection (100 mg)

• Indications:

  • Standard pemetrexed indications (mesothelioma, NSCLC)

• Status: Generic version

• Strengths:

  • Backed by Zydus’s strong domestic distribution network

  • Often available in smaller hospitals or government supply chains

• Limitations:

  • Less documentation/publication compared to Alimta or Pemgem

  • Less widely stocked than 500 mg brands

Additional Information:

• Delivery Time: 12-15 days

💉 BENZZ 180mg Injection Generic Name: Bendamustine Hydrochloride Manufacturer: Intas Pharmaceuticals Ltd Strength: 180 mg Form: Lyophilized Powder for Injection 🩺 Indications:

• Chronic Lymphocytic Leukemia (CLL)

• Non-Hodgkin’s Lymphoma (NHL)

• Occasionally used in Multiple Myeloma in specific regimens

⚙️ Mechanism of Action:

Bendamustine is a bifunctional alkylating agent. It causes DNA cross-linking and strand breaks, which disrupt cancer cell replication and trigger apoptosis (cell death). It also has antimetabolite properties, making it more effective than traditional alkylating agents in certain cases.

💡 Dosage & Administration:

• Reconstituted with sterile water and diluted for IV infusion over 10–60 minutes.

• Dose and schedule vary based on indication and body surface area (e.g., 90 mg/m² on Days 1 & 2 of a 28-day cycle for CLL).

⚠️ Common Side Effects:

• Myelosuppression (low WBC, RBC, platelets)

• Fever, fatigue

• Nausea, vomiting, anorexia

• Mucositis, rashes

• Infusion-related reactions

❄️ Storage:

• Store below 25°C

• Reconstituted solution should be used within specified time limits (usually within 3 hours at room temperature or 24 hours refrigerated)

💉 BENZZ 45mg Injection Generic Name: Bendamustine Hydrochloride Manufacturer: Intas Pharmaceuticals Ltd Strength: 45 mg Form: Lyophilized Powder for Injection 🩺 Indications:

Same as 180mg:

• CLL

• NHL

• Off-label in Multiple Myeloma

💡 Dosage & Administration:

• Smaller strength, ideal for pediatric use, dose titration, or patients with low body surface area.

• IV infusion after reconstitution and dilution, under professional medical supervision.

⚠️ Side Effects:

Similar profile to Benzz 180mg but may be better tolerated in smaller, individualized doses.

❄️ Storage:

Same as above.

💉 NEXBEN 100mg Injection Generic Name: Bendamustine Hydrochloride Manufacturer: Celon Laboratories Ltd Strength: 100 mg Form: Lyophilized Powder for Injection 🩺 Indications:

• First-line and relapsed CLL

• Indolent NHL unresponsive to Rituximab

• Also explored in certain solid tumors and autoimmune diseases (off-label)

⚙️ Mechanism of Action:

Works by alkylating DNA and forming cross-links that inhibit DNA replication and RNA transcription. Also interferes with mitotic checkpoints and promotes apoptosis.

💡 Dosage & Administration:

• Often administered as 100 mg/m² IV on Days 1 & 2 every 28 days for CLL

• Infused over 10–60 minutes, depending on protocol

⚠️ Common Side Effects:

• Diarrhea, vomiting, nausea

• Low platelet count (thrombocytopenia), anemia, neutropenia

• Cough, headache, mucositis

• Injection site reactions

• Secondary malignancies (rare, long-term risk)

❄️ Storage:

• Store below 25°C

• Use reconstituted solution promptly or as per label instructions

Additional Information:

• Delivery Time: 12-15 days

Zidovir 100 Capsule belongs to a group of medicines called antiretrovirals. It is used to treat HIV (human immunodeficiency virus), the virus that can cause AIDS (acquired immunodeficiency syndrome). It helps to control HIV infection so your immune system can work better

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