Skin Care Products

🟦 Reditux 600 mg

• 🏭 Manufacturer: Dr. Reddy’s Laboratories

• 💊 Composition: Rituximab 600 mg (also available in 100 mg & 500 mg vials)

• 📋 Indications:

  • Non-Hodgkin’s Lymphoma (NHL)

  • Chronic Lymphocytic Leukemia (CLL)

  • Rheumatoid Arthritis (with methotrexate)

  • Granulomatosis with polyangiitis & microscopic polyangiitis

• ⚙️ Mechanism: Targets CD20 on B cells → causes cell lysis via ADCC & CDC

• 💉 Administration: Intravenous infusion, under close medical supervision

• ⏱️ Dose Schedule:

  • NHL: 375 mg/m² IV weekly x 4–8 doses

  • RA: 1000 mg IV on days 1 & 15 (with MTX)

• ⚠️ Common Side Effects:

  • Infusion-related reactions (fever, chills, hypotension)

  • Infections (esp. respiratory)

  • Cytopenias, rare PML (progressive multifocal leukoencephalopathy)

• 🧊 Storage: 2–8°C (do not freeze); protect from light

• 🌟 Notable Points:

  • India’s first biosimilar Rituximab (since 2007)

  • Most widely used brand among oncologists

  • Supported by vast post-marketing safety data

🟩 Mabtas 100 mg

• 🏭 Manufacturer: Intas Pharmaceuticals

• 💊 Composition: Rituximab 100 mg (also in 500 mg)

• 📋 Indications: Same as Reditux

• ⚙️ Mechanism: CD20-directed cytolytic antibody

• 💉 Administration: IV infusion; slow titration to avoid infusion reactions

• ⚠️ Common Side Effects:

  • Infusion reactions, fever

  • Hypotension, fatigue, infections

• 🧊 Storage: 2–8°C, do not freeze

• 🌟 Notable Points:

  • Intas is known for quality biosimilars

  • Gaining strong market share as an affordable alternative

  • Used in both cancer centers and rheumatology clinics

🟨 Cytomab 100 mg

• 🏭 Manufacturer: Alkem Laboratories

• 💊 Composition: Rituximab 100 mg (also available in 500 mg)

• 📋 Indications: NHL, CLL, RA, GPA/MPA

• 💉 Administration: IV infusion; pre-medication needed

• ⚠️ Side Effects: Same as above biosimilars

• 🧊 Storage: 2–8°C, protect from freezing and light

• 🌟 Notable Points:

  • Available in limited cancer treatment centers

  • Less widely prescribed compared to Reditux and Mabtas

  • Considered an economical option

🟥 Ritcema 500 mg

• 🏭 Manufacturer: Emcure Pharmaceuticals

• 💊 Composition: Rituximab 500 mg vial

• 📋 Indications: NHL, CLL, RA, GPA/MPA

• 💉 Administration: IV route; slow initial infusion required

• ⚠️ Side Effects:

  • Similar to other rituximab brands: infusion reactions, infections

• 🧊 Storage: Refrigerated (2–8°C)

• 🌟 Notable Points:

  • Emcure’s Rituximab biosimilar

  • Not as widely available or prescribed as Reditux or Mabtas

  • Growing acceptance in government tenders and cost-sensitive settings

💊 Mycidac C

Generic Name: Mycophenolate mofetil + Prednisolone

Dosage Form: Tablet / Capsule

Strength: Commonly Mycophenolate mofetil 500 mg + Prednisolone (variable dose)

🏥 Indications:

• Prevention of organ transplant rejection (kidney, heart, liver)

• Autoimmune diseases needing immunosuppression (e.g., lupus nephritis, rheumatoid arthritis)

📋 Description:

Mycidac C combines two immunosuppressants — Mycophenolate mofetil and Prednisolone — to suppress the immune system, helping prevent organ rejection and control autoimmune conditions.

• Mycophenolate mofetil blocks purine synthesis, reducing lymphocyte proliferation.

• Prednisolone is a corticosteroid that lowers inflammation and immune response.

⚙️ Mechanism of Action:

• Mycophenolate mofetil: Inhibits lymphocyte growth by blocking inosine monophosphate dehydrogenase.

• Prednisolone: Decreases inflammatory mediator production via gene regulation.

💉 Administration:

• Taken orally, usually twice daily.

• Dose adjusted based on patient condition and transplant type.

• Often combined with other immunosuppressants (e.g., cyclosporine).

⚠️ Common Side Effects:

• Nausea, vomiting, diarrhea

• Increased infection risk

• Leukopenia (low white blood cells)

• High blood pressure

• High blood sugar

• Weight gain and mood changes (from prednisolone)

🔍 Precautions:

• Regular blood count monitoring.

• Avoid live vaccines.

• Use cautiously if active infections present.

• Dose adjustments may be necessary for kidney or liver issues.

🏭 Manufacturer:

• Various pharmaceutical companies specializing in transplant and immunosuppressive drugs.

💊 Lorbiqua 25 mg & Lorbiqua 100 mg

Generic Name: Lorlatinib
Brand Name: Lorbiqua
Manufacturer: Pfizer
Drug Class: ALK (Anaplastic Lymphoma Kinase) Tyrosine Kinase Inhibitor
Form: Film-coated tablets
Route: Oral
Indications: Treatment of ALK-positive non-small cell lung cancer (NSCLC)

🔹 Lorbiqua 25 mg ✅ Usage:

Lorbiqua 25 mg tablets are typically used to fine-tune the dosage or provide lower starting doses for patients who may not tolerate the 100 mg dose due to side effects or drug interactions. It is also used for dose adjustments during treatment.

📌 Key Points:

• Used alone or in combination to create custom doses (e.g., 75 mg/day using 3 x 25 mg tablets).

• Suitable for patients with dose-limiting toxicities on 100 mg.

💊 Appearance:

• Pink, round, film-coated tablet with “Pfizer” on one side and “25” on the other.

🔹 Lorbiqua 100 mg ✅ Usage:

Lorbiqua 100 mg is the standard once-daily dose for adult patients with ALK-positive metastatic NSCLC, especially after progression on prior ALK inhibitors like crizotinib, ceritinib, or alectinib.

📌 Key Points:

• First choice in later-line treatment of ALK-positive NSCLC.

• Demonstrates brain penetration, making it effective in treating CNS metastases.

💊 Appearance:

• Pink, oval-shaped, film-coated tablet with “Pfizer” on one side and “100” on the other.

⚙️ Mechanism of Action:

Lorlatinib selectively inhibits ALK and ROS1 tyrosine kinases. These are genetic mutations responsible for driving tumor growth in certain NSCLC subtypes. Lorlatinib blocks the signaling that allows cancer cells to grow and survive.

It is especially potent against resistant ALK mutations and brain metastases due to high CNS penetration.

📋 Clinical Use:

• For adults with ALK-positive metastatic NSCLC whose disease has progressed on:

  • Crizotinib and at least one other ALK inhibitor, OR

  • Alectinib or ceritinib as first-line treatment

⚠️ Common Side Effects:

• Hypercholesterolemia and hypertriglyceridemia

• Peripheral edema

• Weight gain

• CNS effects: mood changes, cognitive impairment

• Fatigue

• Diarrhea

• Joint pain

🧠 CNS effects are more frequent with lorlatinib compared to other ALK inhibitors.

🧪 Monitoring:

• Lipid profile regularly (every 2 weeks initially)

• Liver function tests

• CNS symptoms (confusion, speech changes, mood swings)

❄️ Storage:

• Store below 30°C (86°F)

• Keep in original package to protect from moisture

📦 Shelf Life:

• Generally 24 months from manufacturing when stored properly

🧠 Advantages of Lorbiqua:

• Effective after resistance to first- and second-generation ALK inhibitors

• Penetrates blood-brain barrier, helpful in CNS metastasis

• Active against multiple ALK resistance mutations

🟡 Muslistutra Capsule 🧪 Composition:

• Safed Musli

• Ashwagandha

• Shilajit

• Kaunch Beej, Gokshura, etc. (varies by brand)

✅ Uses:

• Boosts vitality and general stamina

• May improve testosterone levels naturally

• Traditionally used as a rejuvenator (Rasayana) in Ayurveda

💊 Dosage:

• Usually 1 capsule twice daily with milk or as directed by a physician

⚠️ Side Effects:

• Generally safe if taken as per dose

• Mild gastric discomfort in sensitive individuals

📦 Shelf Life: 24–36 months 🌟 Note:

Marketed more as a general strength and energy booster, not as specialized as Musligra Gold.

🟠 Musligra Capsule 🧪 Composition:

• Safed Musli

• Ashwagandha

• Kaunch Beej

• Shilajit

• Gokshura

✅ Uses:

• Promotes sexual stamina, libido, and male fertility

• Used in cases of fatigue, erectile weakness, and low energy

• Improves muscle strength and endurance

💊 Dosage:

• 1–2 capsules per day after meals with milk or water

⚠️ Side Effects:

• Rarely, acidity or minor headaches

• Avoid overdose; consult doctor for long-term use

📦 Shelf Life: 24 months 🌟 Note:

Positioned as a mid-range aphrodisiac supplement, effective for daily stamina.

🟢 Musligra Gold Capsule (Most Potent) 🧪 Composition:

• All of Musligra's ingredients, plus:

  • Swarna Bhasma (Gold ash)

  • Kesar (Saffron)

  • Rajat Bhasma (Silver ash)

  • More concentrated Shilajit extract

✅ Uses:

• Enhances libido, sexual performance, and sperm quality

• Acts as a full body rejuvenator

• Supports mental alertness and mood

💊 Dosage:

• 1 capsule per day, ideally at night with milk

⚠️ Side Effects:

• Safe under proper dose

• Not recommended in hypertension or cardiac conditions without medical advice

📦 Shelf Life: 36 months 🌟 Note:

Premium product used more in performance enhancement and restorative therapy in traditional Ayurvedic practice.